کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5816275 | 1115595 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pretreatment with subeffective doses of Rimonabant attenuates orexigenic actions of orexin A-hypocretin 1
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Pretreatment with subeffective doses of Rimonabant attenuates orexigenic actions of orexin A-hypocretin 1 Pretreatment with subeffective doses of Rimonabant attenuates orexigenic actions of orexin A-hypocretin 1](/preview/png/5816275.png)
چکیده انگلیسی
Recent studies suggest that blockade of cannabinoid CB1 receptors suppresses feeding, an effect observed in humans treated with the cannabinoid CB1 antagonist Rimonabant. A cross-talk between cannabinoids and other systems controlling appetite might exist since cannabinoid receptors are present in hypothalamic neural circuits involved in feeding regulation and energy expenditure. Orexin A-hypocretin 1, an orexigenic peptide, is an ideal candidate to interact with cannabinoid receptors. Both of them play an important role in feeding and they co-localize in similar brain regions. To study this hypothesis we investigated (a) the effects on food intake of either orexin A-hypocretin 1 or the cannabinoid CB1 receptor antagonist Rimonabant in pre-fed rats, and (b) the interaction between them by monitoring the effects of the combined administration of cannabinoids and orexin A-hypocretin 1 in pre-fed rats. The results show that (1) orexin A-hypocretin 1 is a short-term modulator of appetite that increases food intake in pre-fed rats, (2) Rimonabant decreases food intake and (3) such effective and subeffective doses of Rimonabant block the orexigenic effect of orexin A-hypocretin 1. The results support the idea that cannabinoid and orexin A-hypocretin 1 systems share a common mechanism in food intake and indicate that the hypothalamic orexigenic circuits are involved in cannabinoid CB1 receptor antagonism-mediated reduction of appetite.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 54, Issue 1, January 2008, Pages 219-225
Journal: Neuropharmacology - Volume 54, Issue 1, January 2008, Pages 219-225
نویسندگان
Inmaculada Crespo, Raquel Gómez de Heras, Fernando RodrÃguez de Fonseca, Miguel Navarro,