Dipeptidyl-peptidase IV inhibitory activity of peptides derived from tuna cooking juice hydrolysates

► Peptides with MW over 1422 Da showed great DPP-IV inhibitory activities. ► A peptide, PGVGGPLGPIGPCYE (1412.7 Da), showed DPP-IV inhibition with IC50 value of 116.1 μM. ► A peptide, CAYQWQRPVDRIR (1690.8 Da), showed DPP-IV inhibition with IC50 value of 78.0 μM. ► A peptide, PACGGFWISGRPG (1304.6 Da), showed DPP-IV inhibition with IC50 value of 96.4 μM.