Hyperleptinemia in obese adolescents deregulates neuropeptides during weight loss

► Improvement in anthropometric and biochemical measures after interdisciplinary intervention. ► Increase of adiponectin and A/L and reduction in leptin and NPY/AgRP in hyperleptinemic. ► α-MSH and body fat mass (%) = independent predictors to explain leptin concentration. ► Hyperleptinemia deregulates orexigenic and anorexigenic neuropeptides during weight loss.