Antinociceptive properties of nasal delivery of Neurotoxin-loaded nanoparticles coated with polysorbate-80

► Neurotoxin-loaded nanoparticles generate a significant improvement of drug levels in the brain. ► Neurotoxin-loaded nanoparticles overcoated with polysorbate-80 generate a significant improvement of drug levels in the brain. ► The nasal delivery of Neurotoxin generates a significant improvement of drug levels in the brain.