Genetic studies on the ghrelin, growth hormone secretagogue receptor (GHSR) and ghrelin O-acyl transferase (GOAT) genes

► Ghrelin gene polymorphisms interact with environmental weight determinants. ► Ghrelin gene polymorphisms influence hypertension risk and reward seeking behavior. ► Ghrelin receptor gene polymorphisms are important determinants of stature. ► Ghrelin-axis gene polymorphisms are unlikely to influence risk of type 2 diabetes.