Sulfated gastrin stimulates ghrelin and growth hormone release but inhibits insulin secretion in cattle

► We examined the effects of gastrin on plasma levels of hormones in cattle. ► Gastrin increased plasma ghrelin and GH levels, but decreased insulin levels. ► The GHS-R1a is not involved in the gastrin-induced GH release. ► Gastrin had no effect on plasma glucagon and glucose levels. ► Gastrin maintains the homeostasis of blood glucose via down-regulation of insulin.