Ghrelin as a target for gastrointestinal motility disorders

► Ghrelin receptor agonists act as prokinetics in the gastrointestinal (GI) tract. ► Ghrelin mimetics may be useful in treating GI dysmotility by accelerating transit. ► Evidence supports ghrelin agonists in treating gastroparesis and postoperative ileus. ► Further investigation may support ghrelin agonists for functional bowel disorders.