کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10836012 | 1066378 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The metabolic phenotype of SCD1-deficient mice is independent of melanin-concentrating hormone
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We propose that deletion of pro-melanin-concentrating hormone (pMCH) would increase energy expenditure and further improve glucose tolerance in mice lacking stearoyl-coA desaturase-1 (SCD1). To test our hypothesis, we bred and metabolically challenged Pmchâ/â; Scd1â/â double-knockout mice, with comparison to Pmchâ/â mice; Scd1â/â mice and C57Bl/6J controls. Deletion of both Pmch and Scd1 increased both food intake and energy expenditure relative to control mice. Pmchâ/â; Scd1â/â double-knockout mice had improved glucose tolerance relative to control mice. The majority of the metabolic effects were contributed by inactivation of the Scd1 gene. We conclude that the increased food intake and increased energy expenditure of Scd1â/â mice are independent of the neuropeptide melanin-concentrating hormone.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 31, Issue 1, January 2010, Pages 123-129
Journal: Peptides - Volume 31, Issue 1, January 2010, Pages 123-129
نویسندگان
Melissa B. Glier, Pavlos Pissios, Sandra L. Babich, Marcia L.E. Macdonald, Michael R. Hayden, Eleftheria Maratos-Flier, William T. Gibson,