Mechanistic insights on the reactivity of furospirostanes with the 16β,22:22,25-diepoxy-23-acetoxymethyl-24-methyl side chain

- The reactivity of the 16β,22:22,25-diepoxy-23-acetoxymethyl moiety was studied.
- Bromination at C-23 is accompanied by substitution of the 23′-acetoxy moiety.
- Treatment with HBr in AcOH results in substitution of the 23′-acetoxy moiety.
- Furospirostanes were characterized by combined 2D NMR techniques and X-ray studies.