Synthesis and structure of 16,22-diketocholesterol bound to oxysterol-binding protein Osh4

- 16,22-Diketocholesterol is a novel ligand for oxysterol-binding protein Osh4.
- We have determined X-ray structure of 16,-22-diketocholesterol bound to Osh4.
- Our diketocholesterol-Osh4 structure may represent a structural intermediate between open and closed conformations.