Convergent synthesis and cytotoxic activities of 26-thio- and selenodioscin

- A highly stereoselective protocol for 1,2-trans glycosylation of chacotriosyl imidate has been developed.
- 26-Thio- and selenodioscin have been accomplished by convergent block synthesis.
- 26-Thio- and selenodioscin have comparable antitumor activities with dioscin at μM concentrations.