کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10848125 | 1070650 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Characterization of the pharmacokinetics of dioscin in rat
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Dioscin (diosgenyl 2,4-di-O-α-l-rhamnopyranosyl-β-d-glucopyranoside) is an important constituent of some traditional Chinese medicines with several bioactivities. We have investigated the pharmacokinetics of dioscin in rat after intravenous and oral administrations. Compartmental methods were used to perform pharmacokinetic data analysis. The dose-dependent pharmacokinetics of dioscin was characterized after intravenous administrations (0.064, 0.16, 0.4 and 1.0 mg/kg) to rats. There was significant decrease in clearance with increasing dose (4.67 ± 0.09 ml/min/kg (0.064 mg/kg) versus 3.49 ± 0.23 ml/min/kg (1.0 mg/kg), P < 0.05), and the plot of reciprocal clearance values versus the doses was linear (r = 0.909, P < 0.05). After an I.V. dose of 1 mg/kg, simultaneous oral gavage of activated charcoal did not change the pharmacokinetic parameters indicating enterohepatic recycling of dioscin is not important in rat. The absolute oral bioavailability was very low (0.2%). In tissue distribution and bile excretion studies after I.V. and oral administrations, dioscin was shown to undergo a prolonged absorption from the intestinal tract and slow elimination from organs, and only a small amount of drug was recovered in bile. The cumulative amounts of dioscin in feces and urine indicated that the parent drug is mainly excreted in the feces.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Steroids - Volume 70, Issue 8, July 2005, Pages 525-530
Journal: Steroids - Volume 70, Issue 8, July 2005, Pages 525-530
نویسندگان
Ke Li, Yunbiao Tang, John Paul Fawcett, Jingkai Gu, Dafang Zhong,