کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10869784 1073970 2015 22 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ganglioside GM3 as a gatekeeper of obesity-associated insulin resistance: Evidence and mechanisms
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Ganglioside GM3 as a gatekeeper of obesity-associated insulin resistance: Evidence and mechanisms
چکیده انگلیسی
Gangliosides constitute a large family of sialic acid-containing glycosphingolipids which play a key regulatory role in a diverse array of cellular processes, including receptor-associated signalling. Accordingly, the aberrant production of the ganglioside GM3 has been linked to pathophysiological changes associated with obesity, which in turn can lead to metabolic disorders such as insulin resistance and type 2 diabetes mellitus. This review examines the role of GM3 in mediating obesity-induced perturbations in metabolic function, including impaired insulin action. By doing so, we highlight the potential use of therapies targeting GM3 biosynthesis in order to counteract obesity-related metabolic disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 589, Issue 21, 24 October 2015, Pages 3221-3227
نویسندگان
, ,