کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10869809 1073971 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The relevance of EMT in breast cancer metastasis: Correlation or causality?
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
The relevance of EMT in breast cancer metastasis: Correlation or causality?
چکیده انگلیسی
Although major progress has been achieved in treating breast cancer patients, metastatic breast cancer still remains a deadly disease. A full understanding of the process of systemic cancer cell dissemination is therefore critical to develop next generation therapies. A plethora of experimental data points toward a central role of an epithelial to mesenchymal transition (EMT) in the multistep cascade of metastasis formation. However, in patients the data are based on correlative studies which often, but not always, tie the expression of EMT markers to cancer invasion, metastasis and poor clinical outcome. Moreover, the notion that cancer cells are able to switch between different modes of migration asks for a thorough review of the actual relevance of EMT in cancer metastasis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 589, Issue 14, 22 June 2015, Pages 1577-1587
نویسندگان
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