کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10869997 | 1073985 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The coronary artery disease-associated gene C6ORF105 is expressed in human macrophages under the transcriptional control of PPARγ
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The coronary artery disease-associated gene C6ORF105 is expressed in human macrophages under the transcriptional control of PPARγ The coronary artery disease-associated gene C6ORF105 is expressed in human macrophages under the transcriptional control of PPARγ](/preview/png/10869997.png)
چکیده انگلیسی
Coronary artery disease (CAD) is a major cause of morbidity and mortality. Mutations in C6ORF105, associated with decreased gene expression, positively correlate with the risk of CAD in Chinese populations. Moreover, the C6ORF105-encoded protein may play a role in coagulation. Here, we report that C6ORF105 gene expression is lower in circulating mononuclear cells from obese diabetic than lean subjects. Moreover, C6ORF105 is expressed in human macrophages and atherosclerotic lesions, where its expression positively correlates with expression of the transcription factor Peroxisome Proliferator-Activated Receptor (PPAR)γ. Activation of PPARγ increases, in a PPARγ-dependent manner, the expression of C6ORF105 in human macrophages and atherosclerotic lesions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 589, Issue 4, 13 February 2015, Pages 461-466
Journal: FEBS Letters - Volume 589, Issue 4, 13 February 2015, Pages 461-466
نویسندگان
G. Chinetti-Gbaguidi, C. Copin, B. Derudas, J. Vanhoutte, C. Zawadzki, B. Jude, S. Haulon, F. Pattou, N. Marx, B. Staels,