کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10870003 1073985 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
MiR-155 targets TP53INP1 to regulate liver cancer stem cell acquisition and self-renewal
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
MiR-155 targets TP53INP1 to regulate liver cancer stem cell acquisition and self-renewal
چکیده انگلیسی
In liver cancer, miR-155 up-regulation can regulate cancer-cell invasion. However, whether miR-155 expression is associated with liver cancer stem cells (CSCs) remains unknown. Here, we show that miR-155 expression is up-regulated in tumor spheres. Knock-down of miR-155 resulted in suppression of tumor sphere formation, through a decrease in the proportion of CD90+ and CD133+ CSCs and in the expression of Oct4, whereas miR-155 overexpression had the opposite effect. TP53INP1 was determined to be involved in the CSCs-like properties that were regulated by miR-155. Thus, miR-155 may play an important role in promoting the generation of stem cell-like cells and their self-renewal by targeting the gene TP53INP1.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 589, Issue 4, 13 February 2015, Pages 500-506
نویسندگان
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