کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10870017 1073987 2014 27 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Wilms' tumor 1 enhances Cisplatin-resistance of advanced NSCLC
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Wilms' tumor 1 enhances Cisplatin-resistance of advanced NSCLC
چکیده انگلیسی
Wilms' tumor 1 (WT1) is an oncogene that has been correlated with tumor progression, bad prognosis and chemo-resistance in Non-Small-Cell lung cancer (NSCLC). Here, we found that WT1 expression is significantly higher in NSCLCs than in benign controls, and that Cisplatin-resistant patients display a notable increase in WT1 expression following relapse. In vitro, WT1 levels were associated with the IC50 of NSCLC cells and increased along with treatment time and dose of Cisplatin. Furthermore, WT1 enhanced Major Vault Protein (MVP) transcription via binding to its promoter. Therefore, WT1 may be a potential therapeutic target for solving resistance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 588, Issue 24, 20 December 2014, Pages 4566-4572
نویسندگان
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