کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10870072 1073988 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hyperproduction of IL-6 caused by aberrant TDP-43 overexpression in high-fat diet-induced obese mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Hyperproduction of IL-6 caused by aberrant TDP-43 overexpression in high-fat diet-induced obese mice
چکیده انگلیسی
Inclusion of Tat-activating regulatory DNA-binding protein-43 (TDP-43) due to hyperphosphorylation or hyperubiquitination is a cause of neurodegenerative disease. Cellular TDP-43 expression is tightly controlled through a negative feedback loop involving its mRNA. Recently, we reported that the TDP-43-mediated sub-nuclear body is an essential site of interleukin-6 (IL-6) pre-mRNA processing. Here we show that mice fed on a high-fat diet exhibit increased TDP-43 expression in the liver and adipose tissue with a prominent increase in IL-6. TDP-43 depletion in vivo reduces IL-6 production in the liver. Overexpression or depletion of TDP-43 in pre-adipose and adipose cells causes reciprocal alteration of IL-6 expression and RNA processing. Our findings provide evidence for a link between homeostasis of TDP-43 expression and the risk of developing obesity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 589, Issue 15, 8 July 2015, Pages 1825-1831
نویسندگان
, , , , ,