کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10870160 1073992 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tumour necrosis factor alpha-induced neuronal loss is mediated by microglial phagocytosis
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Tumour necrosis factor alpha-induced neuronal loss is mediated by microglial phagocytosis
چکیده انگلیسی
Tumour necrosis factor-α (TNF-α) is a pro-inflammatory cytokine, expressed in many brain pathologies and associated with neuronal loss. We show here that addition of TNF-α to neuronal-glial co-cultures increases microglial proliferation and phagocytosis, and results in neuronal loss that is prevented by eliminating microglia. Blocking microglial phagocytosis by inhibiting phagocytic vitronectin and P2Y6 receptors, or genetically removing opsonin MFG-E8, prevented TNF-α induced loss of live neurons. Thus TNF-α appears to induce neuronal loss via microglial activation and phagocytosis of neurons, causing neuronal death by phagoptosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 588, Issue 17, 25 August 2014, Pages 2952-2956
نویسندگان
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