کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10870192 1073992 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Rab31 is expressed in neural progenitor cells and plays a role in their differentiation
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Rab31 is expressed in neural progenitor cells and plays a role in their differentiation
چکیده انگلیسی
Rab31 is expressed in both GFAP- and nestin- positive fibres in regions of neurogenic potential in the adult mouse brain. To investigate the role of Rab31 in neural progenitor cells (NPCs), we cultured NPCs and found significant levels of Rab31 expression in these cells. Rab31 levels showed a sharp initial decrease and then reappeared gradually in a subpopulation of astrocytes when NPCs were induced to differentiate. Silencing of Rab31 hindered, while overexpression enhanced, the differentiation of NPCs to astrocytes. Our results suggest a previously unrecognised role for Rab31 in influencing the differentiation and fate of NPCs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 588, Issue 17, 25 August 2014, Pages 3186-3194
نویسندگان
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