کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10870503 | 1074008 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Role of neuregulin-1β in dexamethasone-enhanced surfactant synthesis in fetal type II cells
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Role of neuregulin-1β in dexamethasone-enhanced surfactant synthesis in fetal type II cells Role of neuregulin-1β in dexamethasone-enhanced surfactant synthesis in fetal type II cells](/preview/png/10870503.png)
چکیده انگلیسی
It is well established that glucocorticoids elevate the production of fibroblast-pneumocyte factor (FPF), which induces type II cells to synthesize surfactant phospholipids. FPF, however, has not been identified and it is not clear whether it is a single factor or a complex mixture of factors. In this study it has been shown that, when lung fibroblasts are exposed to dexamethasone, the concentration of neuregulin-1β (NRG1β) in conditioned medium is elevated 2-fold (P < 0.05), even though NRG1β gene expression is unaffected. This, together with the finding that exposure of type II cells to NRG1β directly stimulates by 3-fold the rate of phospholipid synthesis (P < 0.05), suggests that NRG1β is a component of FPF that promotes lung development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 588, Issue 6, 18 March 2014, Pages 975-980
Journal: FEBS Letters - Volume 588, Issue 6, 18 March 2014, Pages 975-980
نویسندگان
George King, Garth L. Maker, David Berryman, Robert D. Trengove, Max H. Cake,