کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10870552 | 1074010 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of palmitoylation on the diffusional movement of BKCa channels in live cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effects of palmitoylation on the diffusional movement of BKCa channels in live cells Effects of palmitoylation on the diffusional movement of BKCa channels in live cells](/preview/png/10870552.png)
چکیده انگلیسی
BKCa channels are palmitoylated at a cluster of cysteine residues within the cytosolic linker connecting the 1st and 2nd transmembrane domains, and this lipid modification affects their surface expression. To verify the effects of palmitoylation on the diffusional dynamics of BKCa channels, we investigated their lateral movement. Compared to wild-type channels, the movement of mutant palmitoylation-deficient channels was much less confined and close to random. The diffusion of the mutant channel was also much faster than that of the wild type. Thus, the lateral movement of BKCa channels is greatly influenced by palmitoylation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 588, Issue 5, 3 March 2014, Pages 713-719
Journal: FEBS Letters - Volume 588, Issue 5, 3 March 2014, Pages 713-719
نویسندگان
Sulgi Kim, Byoung-Cheol Lee, A-Ram Lee, Sehoon Won, Chul-Seung Park,