کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10870552 1074010 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of palmitoylation on the diffusional movement of BKCa channels in live cells
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Effects of palmitoylation on the diffusional movement of BKCa channels in live cells
چکیده انگلیسی
BKCa channels are palmitoylated at a cluster of cysteine residues within the cytosolic linker connecting the 1st and 2nd transmembrane domains, and this lipid modification affects their surface expression. To verify the effects of palmitoylation on the diffusional dynamics of BKCa channels, we investigated their lateral movement. Compared to wild-type channels, the movement of mutant palmitoylation-deficient channels was much less confined and close to random. The diffusion of the mutant channel was also much faster than that of the wild type. Thus, the lateral movement of BKCa channels is greatly influenced by palmitoylation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 588, Issue 5, 3 March 2014, Pages 713-719
نویسندگان
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