کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10870562 | 1074010 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Crenactin from Pyrobaculum calidifontis is closely related to actin in structure and forms steep helical filaments
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Crenactin from Pyrobaculum calidifontis is closely related to actin in structure and forms steep helical filaments Crenactin from Pyrobaculum calidifontis is closely related to actin in structure and forms steep helical filaments](/preview/png/10870562.png)
چکیده انگلیسی
Polymerising proteins of the actin family are nearly ubiquitous. Crenactins, restricted to Crenarchaea, are more closely related to actin than bacterial MreB. Crenactins occur in gene clusters hinting at an unknown, but conserved function. We solved the crystal structure of crenactin at 3.2Â Ã
resolution. The protein crystallises as a continuous right-handed helix with 8 subunits per complete turn, spanning 419Â Ã
. The structure of crenactin shows several loops that are longer than in actin, but overall, crenactin is closely related to eukaryotic actin, with an RMSD of 1.6Â Ã
. Crenactin filaments imaged by electron microscopy showed polymers with very similar helical parameters.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 588, Issue 5, 3 March 2014, Pages 776-782
Journal: FEBS Letters - Volume 588, Issue 5, 3 March 2014, Pages 776-782
نویسندگان
Thierry Izoré, Ramona Duman, Danguole Kureisaite-Ciziene, Jan Löwe,