کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10870600 1074014 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chaperone-mediated reversible inhibition of the sarcomeric myosin power stroke
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Chaperone-mediated reversible inhibition of the sarcomeric myosin power stroke
چکیده انگلیسی
Molecular chaperones are required for successful folding and assembly of sarcomeric myosin in skeletal and cardiac muscle. Here, we show that the chaperone UNC-45B inhibits the actin translocation function of myosin. Further, we show that Hsp90, another chaperone involved in sarcomere development, allows the myosin to resume actin translocation. These previously unknown activities may play a key role in sarcomere development, preventing untimely myosin powerstrokes from disrupting the precise alignment of the sarcomere until it has formed completely.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 588, Issue 21, 3 November 2014, Pages 3977-3981
نویسندگان
, , , , , ,