کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10870666 1074017 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genetic disruption of protein phosphatase 5 in mice prevents high-fat diet feeding-induced weight gain
ترجمه فارسی عنوان
اختلال ژنتیکی پروتئین فسفاتاز 5 در موش باعث جلوگیری از افزایش وزن می شود
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
چکیده انگلیسی
The role of serine/threonine protein phosphatase 5 (PP5) in the development of obesity and insulin resistance associated with high-fat diet-feeding (HFD) was examined using PP5-deficient mice (Ppp5c−/−). Despite similar caloric intake, Ppp5c−/− mice on HFD gained markedly less weight and did not accumulate visceral fat compared to wild-type littermates (Ppp5c+/+). On a control diet, Ppp5c−/− mice had markedly improved glucose control compared to Ppp5c+/+ mice, an effect diminished by HFD. However, even after 10 weeks of HFD glucose control in Ppp5c−/− mice was similar to that observed in Ppp5c+/+ mice on the control diet. Thus, PP5 deficiency confers protection against HFD-induced weight gain in mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 587, Issue 23, 29 November 2013, Pages 3869-3874
نویسندگان
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