کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10870695 1074018 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of Connexin/Pannexin containing channels in infectious diseases
ترجمه فارسی عنوان
نقش کانکسین / پانکسین حاوی کانال ها در بیماری های عفونی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
چکیده انگلیسی
In recent years it has become evident that gap junctions and hemichannels, in concert with extracellular ATP and purinergic receptors, play key roles in several physiological processes and pathological conditions. However, only recently has their importance in infectious diseases been explored, likely because early reports indicated that connexin containing channels were completely inactivated under inflammatory conditions, and therefore no further research was performed. However, recent evidence indicates that several infectious agents take advantage of these communication systems to enhance inflammation and apoptosis, as well as to participate in the infectious cycle of several pathogens. In the current review, we will discuss the role of these channels/receptors in the pathogenesis of several infectious diseases and the possibilities of generating novel therapeutic approaches to reduce or prevent these diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 588, Issue 8, 17 April 2014, Pages 1389-1395
نویسندگان
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