کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10870897 | 1074025 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The anti-inflammatory drug celecoxib inhibits t-type Ca2+ currents in spermatogenic cells yet it elicits the acrosome reaction in mature sperm
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Celecoxib (Cx), an anti-inflammatory drug designed to inhibit COX2, can affect some ion channels. T-type (CaV3) channels have been implicated in sperm physiology. Here we report and characterize the Cx induced inhibition of T-type channels in mouse spermatogenic cells. Unexpectedly, Cx can also induce the acrosome reaction (AR), an intracellular Ca2+ ([Ca2+]i) increase and a sperm depolarization. This [Ca2+]i increase possibly results from the ability Cx has to alkalinize intracellular pH (pHi), which is known to activate the sperm specific Ca2+ channel CatSper. As the Cx induced [Ca2+]i increase is sensitive to mibefradil, a CatSper blocker, this channel may mediate the Cx-induced Ca2+ entry leading to the AR. Our observations demonstrate that Cx can compromise fertilization.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 587, Issue 15, 2 August 2013, Pages 2412-2419
Journal: FEBS Letters - Volume 587, Issue 15, 2 August 2013, Pages 2412-2419
نویسندگان
E. Balderas, C. Sánchez-Cárdenas, J.C. Chávez, J.L. de la Vega Beltrán, F. Gómez-Lagunas, C.L. Treviño, A. Darszon,