کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10870926 1074026 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Endoplasmic Reticulum stress reduces COPII vesicle formation and modifies Sec23a cycling at ERESs
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Endoplasmic Reticulum stress reduces COPII vesicle formation and modifies Sec23a cycling at ERESs
چکیده انگلیسی
Exit from the Endoplasmic Reticulum (ER) of newly synthesized proteins is mediated by COPII vesicles that bud from the ER at the ER Exit Sites (ERESs). Disruption of ER homeostasis causes accumulation of unfolded and misfolded proteins in the ER. This condition is referred to as ER stress. Previously, we demonstrated that ER stress rapidly impairs the formation of COPII vesicles. Here, we show that membrane association of COPII components, and in particular of Sec23a, is impaired by ER stress-inducing agents suggesting the existence of a dynamic interplay between protein folding and COPII assembly at the ER.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 587, Issue 19, 1 October 2013, Pages 3261-3266
نویسندگان
, , , , , ,