کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10870937 1074027 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
IFNβ autocrine feedback is required to sustain TLR induced production of MCP-1 in macrophages
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
IFNβ autocrine feedback is required to sustain TLR induced production of MCP-1 in macrophages
چکیده انگلیسی
Chemokines, including MCP-1, are crucial to mounting an effective immune response due to their ability to recruit other immune cells. We show that sustained LPS or poly(I:C)-stimulated MCP-1 production requires an IFNβ-mediated feedback loop. Consistent with this, exogenous IFNβ was able to induce MCP-1 transcription in the absence of other stimuli. Blocking IFNβ signaling with Ruxolitinib, a JAK inhibitor, inhibited MCP-1 transcription. The MCP-1 promoter contains potential STAT binding sites and we demonstrate that STAT1 is recruited upon IFNβ stimulation. Furthermore we find that IL-10 knockout increases MCP-1 production in response to LPS, which may reflect an ability of IL-10 to repress IFNβ production. Overall, these results show the importance of the balance between IFNβ and IL-10 in the regulation of MCP-1.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 587, Issue 10, 21 May 2013, Pages 1496-1503
نویسندگان
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