Stat3 inhibits WTX expression through up-regulation of microRNA-370 in Wilms tumor

► Activation of Stat3 promotes Wilms tumor proliferation. ► Stat3 regulates miR-370 expression at the transcriptional level. ► miR-370 promotes the proliferation of Wilms tumor cells. ► MiR-370 down-regulates WTX by directly targeting the WTX 3′-UTR.