Neurofibrillary tangle-like tau pathology induced by synthetic tau fibrils in primary neurons over-expressing mutant tau

► Synthetic tau fibrils induce tau pathology in primary neurons. ► Fibrils are directly added to neuron medium without any transduction reagent. ► Endogenous mouse tau is recruited into insoluble aggregates. ► Wt and mutant tau demonstrate preferential self-seeding over cross-seeding.