Irradiation-tolerant lung cancer cells acquire invasive ability dependent on dephosphorylation of the myosin regulatory light chain

► Low-invasive cancer cells show diphosphorylation of myosin regulatory light chain. ► High-invasive cancer cells show dephosphorylation of myosin regulatory light chain. ► Diphosphorylation of myosin regulatory light chain inhibits malignant cell invasion.