Biochemical interactions between HIV-1 integrase and reverse transcriptase

► Interactions between HIV-1 reverse transcriptase and integrase have been modeled. ► The model illustrates coordinated regulation of viral DNA production. ► High availability of non-integrated DNA depends on the nature of interactions. ► The indirect mode of interaction provides a strong negative feedback. ► IN·RT and IN·DNA complexes and their formation rates affect RT processivity.