The secreted oligomeric form of α-synuclein affects multiple steps of membrane trafficking

► Secreted α-syn is taken up by dynamin-dependent endocytosis. ► Secreted α-syn enhances the rate of transferrin internalization and recycling. ► Secreted α-syn increases the levels of transferrin receptors at the cell surface. ► The oligomeric form of secreted α-syn is responsible for the effects.