A comparative analysis of the aggregation behavior of amyloid-β peptide variants

► Aggregation properties of an extensive set of Aβ peptide variants were determined. ► C-terminal elongation of Aβ increases aggregation propensity. ► Disease-related mutations of Aβ1-42 variously affect aggregation. ► p3 Peptides resulting from the non-amyloidogenic pathway aggregate profoundly. ► Biotinylation affects the aggregation of Aβ.