Quaternary structure of human, Drosophila melanogaster and Caenorhabditis elegans MFE-2 in solution from synchrotron small-angle X-ray scattering

► MFE-2s from different organisms share homologous domains in different compilations. ► SCP-2L is a distinct and detached domain in human and Caenorhabditis elegans MFE-2s. ► The first structural model of full-length human MFE-2 is presented.