MicroRNA-21 mediates the rapamycin-induced suppression of endothelial proliferation and migration

► miR-21 expression was upregulated by rapamycin treatment. ► miR-21 deletion abolished rapamycin-induced inhibition on endothelial growth and mobility. ► RhoB was a direct target gene of miR-21. ► Knock-down of Raptor mimicked the augmentation of miR-21 induced by rapamycin.