FBXW7-mediated degradation of CCDC6 is impaired by ATM during DNA damage response in lung cancer cells

► Cullin1-based ubiquitin E3 ligase is required for the degradation of CCDC6. ► FBXW7 interacts with CCDC6. ► FBXW7 regulates the stability of CCDC6. ► FBXW7-mediated CCDC6 degradation is impaired in response to DNA damage. ► Phosphorylation of CCDC6 at Thr434 by ATM during DNA damage response prevents FBXW7-mediated CCDC6 degradation.