A new family of bacterial DNA repair proteins annotated by the integration of non-homology, distant homology and structural bioinformatic methods

► DUF2086 is predicted bioinformatically to be a new DNA repair protein family. ► The synergy between homology, structural and non-homology methods is exploited. ► The first oxidative demethylation repair enzymes in Firmicutes and Planctomycetes.