Glycogen synthase kinase-3β regulates leucine-309 demethylation of protein phosphatase-2A via PPMT1 and PME-1

► GSK-3β can inhibit PP2A by increasing the inhibitory L309-demethylation. ► GSK-3β can regulate PME-1 and PPMT1 mRNA and protein levels. ► GSK-3 could negatively regulate PP2A regulatory subunit (PP2AB) protein level.