The microtubule associated protein syntabulin is required for glucose-stimulated and cAMP-potentiated insulin secretion

► Syntabulin is expressed in pancreas and insulin-secreting β-cells. ► Syntabulin co-localizes with microtubule and insulin-containing granules. ► Syntabulin is required for glucose-stimulated insulin secretion. ► Syntabulin is essential for cAMP-Epac2-potentiated insulin secretion.