Annexin A9 is a periplakin interacting partner in membrane-targeted cytoskeletal linker protein complexes

► Annexin A9 immunoprecipitates with N-terminus of a cytolinker protein periplakin. ► Periplakin and annexin A9 co-localise in epithelia and epidermis. ► Hyperphoshorylation induced by Okadaic acid aggregates periplakin and annexin A9. ► Annexin A9 localisation in the epidermis is not affected by ablation of periplakin. ► Annexin A9 can provide a way to generate a sub-plasmamembrane scaffold for skin barrier assembly.