PANcreatic-DERived factor: Novel hormone PANDERing to glucose regulation

► PANDER serves as a novel hormone regulating glycemic levels. ► PANDER is positively regulated by glucose and insulin. ► PANDER impacts pancreatic β-cell glucose-stimulated insulin secretion. ► PANDER interacts with liver and increases hepatic glucose production. ► High fat animal models demonstrate increased PANDER expression and hepatic action.