The Mg2+ transporter MagT1 partially rescues cell growth and Mg2+ uptake in cells lacking the channel-kinase TRPM7

► We analyzed the role of the Mg2+ transporter MagT1 in DT40 B cells lacking the Mg2+ regulator TRPM7. ► Gene expression of MagT1 is upregulated in TRPM7−/− cells. ► Overexpressing MagT1 in TRPM7−/− cells partially rescues their growth in the absence of excess Mg2+. ► Overexpressing MagT1 in TRPM7−/− cells partially rescues their ability to uptake Mg2+.