HVEM-deficient mice fed a high-fat diet are protected from adipose tissue inflammation and glucose intolerance

► We examined the effect of HVEM deficiency on obesity-induced inflammation and complications. ► HVEM-deficient mice or wild type mice were fed a high-fat diet (HFD). ► HFD-fed HVEM-deficient mice elicited a reduction in the number of macrophage/T cells infiltrated into adipose tissue. ► Proinflammatory cytokine levels were also decreased in the adipose tissue of HFD-fed HVEM. ► Glucose intolerance and insulin sensitivity were markedly improved in the HFD-fed HVEM-deficient mice.