The yeast metacaspase is implicated in oxidative stress response in frataxin-deficient cells

► Sensitivity of yeast frataxin-deficient cells to hydrogen peroxide is partially mediated by metacaspase. ► In the absence of metacaspase, frataxin-deficient cells recover antioxidant capacity and heme biosynthesis. ► Metacaspase is implicated in mitochondrial energy metabolism and intracellular redox control.