کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10871548 | 1074058 | 2012 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
14-3-3Ï regulation by p53 mediates a chemotherapy response to 5-fluorouracil in MCF-7 breast cancer cells via Akt inactivation
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
We previously demonstrated that 14-3-3Ï was downregulated in 5-fluorouracil (5-Fu)-resistant MCF-7 breast cancer cells (MCF-7/5-Fu). Here, we found that stably enhanced 14-3-3Ï expression strengthened the effects of 5-Fu, Mitoxantrone and cDDP. 14-3-3Ï stabilised the p53 protein and bound Akt to inhibit its activity and its downstream targets: survivin, Bcl-2 and NF-κB-p50. In addition, decreased p53 expression, but not promoter hypermethylation, was responsible for the downregulation of 14-3-3Ï in MCF-7/5-Fu cells. Meanwhile, initial treatments with high concentrations of 5-Fu clearly induced 14-3-3Ï and p53 expression in a time-dependent manner. 14-3-3Ï-mediated molecular events that synergise with p53 may play important roles in the chemotherapy of breast cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 586, Issue 2, 20 January 2012, Pages 163-168
Journal: FEBS Letters - Volume 586, Issue 2, 20 January 2012, Pages 163-168
نویسندگان
Guopei Zheng, Yan Xiong, Sisi Yi, Weijia Zhang, Bo Peng, Qiong Zhang, Zhimin He,