Identification of catechols as histone-lysine demethylase inhibitors

► Catechols were identified as inhibitors of the histone-lysine demethylase KDM4C. ► The inhibitors were selective towards KDM4C and KDM6A and had no effect on PHF8. ► One inhibitor restored H3K9me3 levels in KDM4C transfected U2-OS cells.