کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10871590 1074062 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The multiple and enigmatic roles of guanylyl cyclase C in intestinal homeostasis
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
The multiple and enigmatic roles of guanylyl cyclase C in intestinal homeostasis
چکیده انگلیسی
Guanylyl cyclase C (GC-C) is predominantly expressed in intestinal epithelial cells and serves as the receptor for the gastrointestinal hormones guanylin and uroguanylin, and the heat-stable enterotoxin, the causative agent for Travellers' Diarrhea. Activation of GC-C results in an increase in intracellular levels of cGMP, which can regulate fluid and ion secretion, colon cell proliferation, and the gut immune system. This review highlights recent findings arising from studies in the GC-C knock-out mouse, along with enigmatic results obtained from the first descriptions of human disease caused by mutations in the GC-C gene. We provide some insight into these new findings and comment on areas of future study, which may enhance our knowledge of this evolutionarily conserved receptor and signaling system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 586, Issue 18, 31 August 2012, Pages 2835-2840
نویسندگان
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