Antibody-antigen pair probed by combinatorial approach and rational design: Bringing together structural insights, directed evolution, and novel functionality

► Antibodies are extraordinary template for combinatorial and rational improvements. ► Reactibodies are novel catalytic scavengers with predefined specificity. ► Catalytic antibodies towards distinct pathogens - elaboration of catalytic vaccines. ► 2D screening - antibody versus antigen in solving of the “Chicken and Egg” problem.